MBD1 antibody (CF®405S)

Catalog No. ABIN7657011

This anti-MBD1 antibody is a Mouse Monoclonal antibody detecting MBD1 in IHC and IHC (fp). Suitable for Human.

Quick Overview for MBD1 antibody (CF®405S) (ABIN7657011)

Target: MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This MBD1 antibody is conjugated to CF®405S

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: CPTC-MBD1-1

Product Details anti-MBD1 Antibody (CF®405S)

Purpose: MBD1 (Methyl-CpG Binding Domain Protein 1)(CPTC-MBD1-1), CF405S conjugate

Characteristics: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. MBD1 has also been predicted to be involved in the development and progression of tumors, and it has been shown that MBD1 is significantly upregulated in pancreatic cancer tissues when compared with surrounding normal tissues. Furthermore, MBD1 may serve as a potential therapeutic target for pancreatic cancer. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant human MBD1 protein

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: Human tonsil or colon (IHC).

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for MBD1

Target: MBD1 (Methyl-CpG Binding Domain Protein 1 (MBD1))

Alternative Name: MBD1

Background:

Synonyms: CXXC-type zinc finger protein 3, CXXC3, MBD1, MECP1 COMPLEX, Methyl-CpG-binding domain protein 1 (MBD1), Protein containing methyl-CpG-binding domain 1 (PCM1), Regulator of fibroblast growth factor 2 (FGF 2) transcription (RFT)

Gene Symbol: MBD1

Molecular Weight: ~80 kDa

Gene ID: 4152

UniProt: Q9UIS9