PD-1 antibody (CF®488A)

Catalog No. ABIN7658968

This Mouse Monoclonal antibody specifically detects PD-1 in IHC and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for PD-1 antibody (CF®488A) (ABIN7658968)

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This PD-1 antibody is conjugated to CF®488A

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: NAT105

Product Details anti-PD-1 Antibody (CF®488A)

Purpose: PDCD1 / PD1 / CD279 (Programmed Cell Death 1)(NAT105), CF488A conjugate

Characteristics: PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: TY cells (human T/NK cell Leukemia)

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: TY cells. Tonsil.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for PD-1

Target: PD-1 (PDCD1) (Programmed Cell Death 1 (PDCD1))

Alternative Name: CD279

Background:

Synonyms: CD279, hPD-1, hSLE1, PD1, PDCD1, Programmed Cell Death Protein 1, Protein PD-1, SLEB2, Systemic lupus erythematosus susceptibility 2

Gene Symbol: PDCD1

Tissue Expression: B-cells|Myeloid cells|T-cells

Molecular Weight: 55 kDa

Gene ID: 5133

UniProt: Q15116

Pathways: Cancer Immune Checkpoints