RPSA/Laminin Receptor antibody

Catalog No. ABIN7659650

The Mouse Monoclonal anti-RPSA/Laminin Receptor antibody has been validated for IF and FACS. It is suitable to detect RPSA/Laminin Receptor in samples from Human.

Quick Overview for RPSA/Laminin Receptor antibody (ABIN7659650)

Target: RPSA/Laminin Receptor (RPSA) (Ribosomal Protein SA (RPSA))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RPSA/Laminin Receptor antibody is un-conjugated

Application: Immunofluorescence (IF), Flow Cytometry (FACS)

Clone: RPSA-2699

Product Details anti-RPSA/Laminin Receptor Antibody

Purpose: Laminin Receptor / RPSA (Marker of Metastatic Potential)(RPSA/2699)

Characteristics: Laminins, a family of extracellular matrix glycoproteins, are the major non-collagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. Reportedly, level of laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant full-length human RPSA protein

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: MCF-7, MDA-MB-453, SK-BR3, THP1, HL60, HeLa or HEK293 cells. Breast, Colon or Ovarian Carcinoma, Tonsil.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, no BSA, no azide

Preservative: Without preservative

Storage: -20 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Store at -20 °C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for RPSA/Laminin Receptor

Target: RPSA/Laminin Receptor (RPSA) (Ribosomal Protein SA (RPSA))

Alternative Name: Laminin Receptor

Background:

Synonyms: 34/67 kDa Laminin Receptor, 37 kDa Laminin Receptor precursor, 37/67 kDa Laminin Receptor, 37LRP, 40S Ribosomal Protein SA, 67 kDa Laminin Receptor, 67LR, Colon Carcinoma Laminin-binding Protein, LAMBR, Laminin receptor 1, Laminin-binding Protein precursor p40, LAMR1, LBP/p40, LRP/LR, Multidrug resistance-associated protein MGr1-Ag, NEM/1CHD4, Ribosomal Protein SA (RPSA)

Gene Symbol: RPSA

Molecular Weight: 37-67 kDa

Gene ID: 3921

UniProt: P08865

Pathways: Ribonucleoprotein Complex Subunit Organization, Ribosome Assembly