Transferrin antibody (AA 311-445) (CF®405S)

Catalog No. ABIN7661004

This anti-Transferrin antibody is a Mouse Monoclonal antibody detecting Transferrin in IHC and IHC (fp). Suitable for Human.

Quick Overview for Transferrin antibody (AA 311-445) (CF®405S) (ABIN7661004)

Target: Transferrin (TF)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Transferrin antibody is conjugated to CF®405S

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: TF-3001

Product Details anti-Transferrin Antibody (CF®405S)

Binding Specificity: AA 311-445

Purpose: Transferrin (Early Marker of Oligodendrocytes)(TF/3001), CF405S conjugate

Characteristics: Iron (Fe) is a tightly metabolically controlled mineral and growth factor present in all living cells. Iron not bound in erythrocyte hemoglobin is transported by transferrin (Tf), the iron transport protein of vertebrate serum. The transferrin protein contains two homologous domains, each of which contain an Fe-binding site. The majority of transferrin is synthesized in the liver and secreted into the blood, but it is also produced in lower amounts in testis and brain as well as in oligodendrocytes, where transferrin is an early marker of oligodendrocyte differentiation. From the blood, transferrin is internalized by erythroblasts and reticulocytes upon binding the transferrin receptor (TfR), also designated CD71, through a system of coated pits and vesicles. After Fe release, transferrin is returned to the extracellular medium, where it can be reused. Defects in the transferrin gene results in atransferrinemia, a rare autosomal recessive disorder characterized by microcytic anemia and iron loading. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment (around aa 311-445) of human TF protein

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: Jurkat, HeLa, MCF-7 or K562 cells. Human liver.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for Transferrin

Target: Transferrin (TF)

Alternative Name: Transferrin

Background:

Synonyms: Apotransferrin, Beta-1 metal-binding globulin, Serotransferrin, Siderophilin, TF, TFQTL1, Transferrin

Gene Symbol: TF

Molecular Weight: 79 kDa

Gene ID: 7018

UniProt: P02787

Pathways: Transition Metal Ion Homeostasis