TTR antibody (CF®568)

Catalog No. ABIN7661065

This Mouse Monoclonal antibody specifically detects TTR in WB. It exhibits reactivity toward Human.

Quick Overview for TTR antibody (CF®568) (ABIN7661065)

Target: TTR (Transthyretin (TTR))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This TTR antibody is conjugated to CF®568

Application: Western Blotting (WB)

Clone: CPTC-TTR-1

Product Details anti-TTR Antibody (CF®568)

Purpose: Transthyretin (Prealbumin)(CPTC-TTR-1), CF568 conjugate

Characteristics: Prealbumin, also designated transthyretin, is a major thyroid-hormone binding protein involved in transporting thyroxine from the bloodstream to the brain. Prealbumin is located in the cytoplasm and in the vesicles of developing rat brain cells, and is thought to be transported there from the cerebrospinal fluid via endocytosis. Sequence variants of this protein have been identified in amyloid fibrils from patients with familial amyloidotic polyneuropathy (FAP), the most common form of hereditary systemic amyloidosis. Although the biologically active form of Prealbumin is a tetramer, the amyloidogenic intermediate is thought to be a monomeric species. Prealbumin also binds to the retinol carrier protein RBP (retinol-binding protein). Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant human full-length protein

Isotype: IgG2a, kappa

Application Details

Application Notes: ELISA: For coating, order Ab without BSA, Western blot 1-2 μg/mL, Optimal dilution for a specific application should be determined.. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody

Comment:

Positive Control: HepG2, Pancreas and liver.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for TTR

Target: TTR (Transthyretin (TTR))

Alternative Name: Transthyretin

Background:

Synonyms: Transthyretin, PALB, HsT2651, prealbumin, amyloidosis type 1, ATTR, TBPA, CTS, CTS1, carpal tunnel syndrome 1, thyroxine-binding prealbumin, prealbumin, HEL111, TTR protein, Epididymis luminal protein 111, prealbumin thyroxine binding, senile systemic amyloidosis antibody

Gene Symbol: TTR

Molecular Weight: 15 kDa

Gene ID: 7276

UniProt: P02766

Pathways: Hormone Transport