Uroplakin 1B antibody (AA 109-229)

Catalog No. ABIN7661692

This Mouse Monoclonal antibody specifically detects Uroplakin 1B in IHC and IHC (fp). It exhibits reactivity toward Human.

Quick Overview for Uroplakin 1B antibody (AA 109-229) (ABIN7661692)

Target: Uroplakin 1B (UPK1B)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Uroplakin 1B antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone: UPK1B-3273

Product Details anti-Uroplakin 1B Antibody

Binding Specificity: AA 109-229

Purpose: Uroplakin 1B (Urothelial Differentiation Marker)(UPK1B/3273)

Characteristics: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. UPK1B is expressed by terminally differentiated urothelial cells. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant fragment (around aa 109-229) of human Uroplakin 1B (UPK1B) protein

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Positive Control: Urinary Bladder (IHC).

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS, no BSA, no azide

Preservative: Without preservative

Storage: -20 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Store at -20 °C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for Uroplakin 1B

Target: Uroplakin 1B (UPK1B)

Alternative Name: Uroplakin 1B

Background:

Synonyms: Tetraspanin-20, Tspan-20, TSPAN20, UP1b, UPIb, UPK1B, Uroplakin-1b

Gene Symbol: UPK1B

Molecular Weight: ~30 kDa

Gene ID: 7348

UniProt: O75841