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Recombinant VTCN1 antibody

This anti-VTCN1 antibody is a Rabbit Monoclonal antibody detecting VTCN1 in IHC, FACS, IF and IHC (fp). Suitable for Human.
Catalog No. ABIN7661796

Quick Overview for Recombinant VTCN1 antibody (ABIN7661796)

Target

See all VTCN1 Antibodies
VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))

Antibody Type

Recombinant Antibody

Reactivity

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Human

Host

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Rabbit

Clonality

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Monoclonal

Conjugate

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This VTCN1 antibody is un-conjugated

Application

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Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Formalin-fixed Paraffin-embedded Sections) (IHC (fp))

Clone

B7H4-2652R
  • Purpose

    B7-H4 (Immuno-Inhibitory Protein) (B7H4/2652R)

    Characteristics

    B7-H4 (B7-homolog 4), belongs to the B7 immunoglobulin superfamily of ligand-lymphocyte interacting proteins. Expressed primarily on the membrane of lymphoid cells, B7-H4 is an immuno-inhibitory protein that interacts with receptors on the surface of T lymphocytes, thus mediating cellular and humoral immune responses. Overexpression of the B7-H4 protein is associated with certain malignancies, including ovarian and breast cancer, as its interaction with T cells suppresses tumor-associated immunity. Current research suggests that, similar to Mucin 16 (CA-125), B7-H4 may be a useful biomarker for the early detection of ovarian cancer.Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

    Immunogen

    Recombinant human B7-H4 protein fragment

    Isotype

    IgG
  • Application Notes

    Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. ELISA: 2-4 μg/m for coating order Ab without BSA. Immunohistology (formalin): 1-2 μg/mL for 30 minutes at RT. Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 minutes followed by cooling at RT for 20 minutes. Optimal dilution for a specific application should be determined by user

    Comment

    Positive Control: HeLa or MCF-7 Cells. Ovary, Pancreas, Placenta or Spleen.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 mg/mL

    Buffer

    PBS, no BSA, no azide

    Preservative

    Without preservative

    Storage

    -20 °C

    Storage Comment

    Stable at room temperature or 37°C for 7 days.

    Store at -20 °C. Protect fluorescent conjugates from light

    Expiry Date

    24 months
  • Target

    VTCN1 (V-Set Domain Containing T Cell Activation Inhibitor 1 (VTCN1))

    Alternative Name

    B7-H4

    Background

    Synonyms: B7-H4, B7H4, B7X, B7 family member, H4, B7 homolog 4, B7 superfamily member 1, B7S1, B7 family member H4

    Gene Symbol: VTCN1

    Molecular Weight

    35 kDa

    Gene ID

    79679

    UniProt

    Q7Z7D3
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