Recombinant VLDLR antibody (C-Term) (CF®740)

Catalog No. ABIN7661871

This anti-VLDLR antibody is a Rabbit Monoclonal antibody detecting VLDLR in . Suitable for Human and Rat.

Quick Overview for Recombinant VLDLR antibody (C-Term) (CF®740) (ABIN7661871)

Target: VLDLR (Very Low Density Lipoprotein Receptor (VLDLR))

Antibody Type: Recombinant Antibody

Reactivity: Human, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This VLDLR antibody is conjugated to CF®740

Application: Please inquire

Clone: VLDLR-2896R

Product Details anti-VLDLR Antibody (CF®740)

Binding Specificity: C-Term

Purpose: VLDL-Receptor (Very Low Density Lipoprotein Receptor)(VLDLR/2896R), CF740 conjugate

Characteristics: VLDLR (very low density lipoprotein receptor) is a member of the LDL receptor gene family, which includes LDL receptor, LRP, megalin, VLDLR and ApoER2. The LDL receptor family is characterized by a cluster of cysteine-rich class A repeats, epidermal growth factor (EGF)-like repeats, YWTD repeats and an O-linked sugar domain. VLDLR associates with RAP (receptor associated protein) during receptor folding, and RAP facilitates the secretion of the extracellular region of VLDLR. VLDLR is thought to mediate the interaction of extracellular Reelin and cytosolic mDab1 (mammalian disabled protein), which activates a tyrosine kinase. This pathway regulates the migration of neurons along the radial glial fiber network during brain development. Primary antibodies are available purified, or with a selection of fluorescent CF® Dyes and other labels. CF® Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF®405S and CF®405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.

Immunogen: Recombinant human VLDLR fragment from c-terminal

Isotype: IgG

Application Details

Application Notes: For coating for ELISA, order Ab without BSA. Higher concentration may be required for direct detection using primary antibody conjugates than for indirect detection with secondary antibody. Optimal dilution and staining procedure for a specific application should be determined by user. Recommended starting concentrations for titration are 1-2 μg/mL for most applications, or 1 μg/million cells/100 μLfor flow cytometry

Comment:

Positive Control: HeLa or U-251 cells. Pancreas, Cerebellum, Heart or Skeletal Muscle.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % rBSA, 0.05 % azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Protect from light

Storage: 4 °C

Storage Comment:

Stable at room temperature or 37°C for 7 days.

Protect from light

Store at 2 to 8°C. Protect fluorescent conjugates from light

Expiry Date: 24 months

Target Details for VLDLR

Target: VLDLR (Very Low Density Lipoprotein Receptor (VLDLR))

Alternative Name: VLDL Receptor

Background:

Synonyms: Very low-density lipoprotein receptor, VLDL receptor, VLDL-R, VLDLR

Gene Symbol: VLDLR

Molecular Weight: 143-161 kDa

Gene ID: 7436

UniProt: P98155

Pathways: Cellular Response to Molecule of Bacterial Origin