ADAM10 antibody

Catalog No. ABIN7669976

This anti-ADAM10 antibody is a Mouse Monoclonal antibody detecting ADAM10 in FACS. Suitable for Human.

Quick Overview for ADAM10 antibody (ABIN7669976)

Target: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ADAM10 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: 11G2

Product Details anti-ADAM10 Antibody

Purpose: Purified Anti-Human ADAM10 Antibody[11G2]

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: ≥ 1 mg/mL

Buffer: Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze / thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for ADAM10

Target: ADAM10 (ADAM Metallopeptidase Domain 10 (ADAM10))

Alternative Name: ADAM10

Background: CDw,ADAM,ADAM metallopeptidase domain,a disintegrin and metalloprotease domain,a disintegrin and metalloproteinase domain,disintegrin and metalloproteinase domain-containing protein,ADAM10,AD10,AD18,CD156c,CDw156,HsT18717,MADM,RAK,kuz,Kuzbanian,a disintegrin and metalloprotease domain 10,a disintegrin and metalloproteinase domain 10,ADAM metallopeptidase domain 10,CD156c antigen,disintegrin and metalloproteinase domain-containing protein 10,Kuzbanian protein homolog,Mammalian disintegrin-metalloprotease,ADAM metallopeptidase domain 10,CD156c,CDw156,HsT18717,kuz,MADM,AD 10,ADA10,ADAM 10,CD 156c,disintegrin and metalloproteinase domain containing protein 10,Drosophila,homolog of,HsT 18717,Mammalian disintegrin metalloprotease,ADAM10 (also known as Kuzbanian, mammalian disintegrin metalloprotease, myelin-associated metalloproteinase) is a member of the ADAM family that contains a disintegrin and metalloprotease-like domain . Like other membrane-anchored ADAMs, ADAM10 consists of the following domains, pro with a cysteine switch and furin cleavage sequence, catalytic with the zinc-binding site and Met-turn expected for reprolysins, disintegrin-like, cysteine-rich, EGF-like, transmembrane, and cytoplasmic. ADAM10 is highly conserved, with 97 % amino acid identity between mouse, rat, bovine and human and 45 % identity between mouse and Drosophila. The active enzyme processes notch, notch ligand delta, and amyloid protein precursor at the alpha site, playing an important role in neurogenesis . It also processes the 26 kDa membrane-anchored pro-tumor necrosis factor-alpha (TNF-alpha ) to the 17 kDa mature TNF-alpha. It cleaves myelin basic protein and type IV collagen. ADAM10 is widely expressed in tissues and resides both on the cell surface and in the cell.

UniProt: O14672

Pathways: Notch Signaling, EGFR Signaling Pathway