CD74 antibody

Catalog No. ABIN7670066

This anti-CD74 antibody is a Mouse Monoclonal antibody detecting CD74 in FACS. Suitable for Human.

Quick Overview for CD74 antibody (ABIN7670066)

Target: CD74 (HLA-DR-gamma (CD74))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD74 antibody is un-conjugated

Application: Flow Cytometry (FACS)

Clone: LL1

Product Details anti-CD74 Antibody

Purpose: Purified Anti-Human CD74 Antibody[LL1]

Isotype: IgG1, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: ≥ 1 mg/mL

Buffer: Phosphate buffered solution, pH 7.2, containing 0.05 % proclin 300.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: avoid freeze / thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C valid for 12 months or -20°C valid for long term storage, avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for CD74

Target: CD74 (HLA-DR-gamma (CD74))

Alternative Name: CD74

Background: HLA class II histocompatibility antigen gamma chain,HLADG,Ia antigen-associated invariant chain,Ia-GAMMA II,Ii,p33,CD74 HLA-DR antigens-associated invariant chain,DHLAG,CD74, invariant chain,CD 74,CD74 antigen,CD74 antigen (invariant polypeptide of major histocompatibility complex,CD74 Molecule,class II antigen-associated),class II invariant chain,CLIP,Gamma chain of class II antigens,HG2A,HLA DR antigens associated invariant chain,HLA DR gamma,HLADR antigens associated invariant chain,HLA-DR antigens-associated invariant chain,HLA-DR-gamma,Ia antigen associated invariant chain,Ia associated invariant chain,Ia gamma,Ia-GAMMA,Invariant polypeptide of major histocompatibility complex class II antigen associated,la-gamma,major histocompatibility complex,Major histocompatibility complex class II invariant chain,MHC HLA DR gamma chain,MHC HLA-DR gamma chain,p35,Protein 41,CD74,DHLAG,HLA class II histocompatibility antigen gamma chain,HLADG,Ia antigen-associated invariant chain,p33,CD 14,CD_antigen=CD14,CD14,CD14 antigen,CD14 Molecule,LPS-R,Mo2,Monocyte differentiation antigen CD14,Monocyte differentiation antigen CD14 urinary form,membrane-bound form,Myeloid cell specific leucine rich glycoprotein,Myeloid cell-specific leucine-rich glycoprotein,Plays a critical role in MHC class II antigen processing by stabilizing peptide-free class II alpha/beta heterodimers in a complex soon after their synthesis and directing transport of the complex from the endoplasmic reticulum to the endosomal/lysosomal system where the antigen processing and binding of antigenic peptides to MHC class II takes place. Serves as cell surface receptor for the cytokine MIF. Class-II-associated invariant chain peptide Binds to the peptide-binding site of MHC class II alpha/beta heterodimers forming an alpha-beta-CLIP complex, thereby preventing the loading of antigenic peptides to the MHC class II complex until its release by HLA-DM in the endosome.1 Publication Isoform p41 Stabilizes the conformation of mature CTSL by binding to its active site and serving as a chaperone to help maintain a pool of mature enzyme in endocytic compartments and extracellular space of antigen-presenting cells (APCs). Has antiviral activity by stymieing the endosomal entry of Ebola virus and coronaviruses, including SARS-CoV-2. Disrupts cathepsin-mediated Ebola virus glycoprotein processing, which prevents viral fusion and entry. This antiviral activity is specific to p41 isoform.

UniProt: P04233

Pathways: Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Negative Regulation of intrinsic apoptotic Signaling, Cancer Immune Checkpoints