CD8 alpha antibody (APC)

Catalog No. ABIN7670216

This anti-CD8 alpha antibody is a Rat Monoclonal antibody detecting CD8 alpha in FACS. Suitable for Mouse.

Quick Overview for CD8 alpha antibody (APC) (ABIN7670216)

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This CD8 alpha antibody is conjugated to APC

Application: Flow Cytometry (FACS)

Clone: 2-43

Product Details anti-CD8 alpha Antibody (APC)

Purpose: APC Anti-Mouse CD8a Antibody[2.43]

Isotype: IgG2b, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 5 μL/tests

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09 % stabilizer and 1 % protein protectant.

Handling Advice: Please protected from prolonged exposure to light and do not freeze.

Storage: 4 °C

Storage Comment: This product can be stored at 2-8°C for 12 months.

Expiry Date: 12 months

Target Details for CD8 alpha

Target: CD8 alpha (CD8A) (CD8a Molecule (CD8A))

Alternative Name: CD8a

Background: CD19 Molecule,CD19 Antigen,Differentiation Antigen CD19,B-Lymphocytes Surface Antigen B4,T-cell Surface Antigen Leu-12,CVID3,B4,B-lymphocyte Antigen CD19,CD8, also known as Lyt-2, Ly-2, or T8, consists of disulfide-linked α and β chains that form the α(CD8a)/β(CD8b) heterodimer and α/α homodimer. CD8a is a 34 kD protein that belongs to the immunoglobulin family. The CD8 α/β heterodimer is expressed on the surface of most thymocytes and a subset of mature TCR α/β T cells. CD8 expression on mature T cells is non-overlapping with CD4. The CD8 α/α homodimer is expressed on a subset of γ/δ TCR-bearing T cells, NK cells, intestinal intraepithelial lymphocytes, and lymphoid dendritic cells. CD8 is an antigen co-receptor on T cells that interacts with MHC class I on antigen-presenting cells or epithelial cells. CD8 promotes T cell activation through its association with the TCR complex and protein tyrosine kinase lck.

UniProt: P15391

Pathways: TCR Signaling