Integrin beta 7 antibody (PE)

Catalog No. ABIN7670235

This Rat Monoclonal antibody specifically detects Integrin beta 7 in FACS. It exhibits reactivity toward Human.

Quick Overview for Integrin beta 7 antibody (PE) (ABIN7670235)

Target: Integrin beta 7 (ITGB7)

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This Integrin beta 7 antibody is conjugated to PE

Application: Flow Cytometry (FACS)

Clone: FIB504

Product Details anti-Integrin beta 7 Antibody (PE)

Purpose: PE Anti-Human Integrin β7 Antibody[FIB504]

Immunogen: E-AB-F09832D

Isotype: IgG2a, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 5 μL/tests

Buffer: Phosphate buffered solution, pH 7.2, containing 0.09 % stabilizer and 1 % protein protectant.

Handling Advice: Please protected from prolonged exposure to light and do not freeze.

Storage: 4 °C

Storage Comment: This product can be stored at 2-8°C for 12 months.

Expiry Date: 12 months

Target Details for Integrin beta 7

Target: Integrin beta 7 (ITGB7)

Alternative Name: Integrin beta7

Background: CEACAM1a,Bgp,Integrin β7 is a 130 kD glycoprotein also known as integin βp. It is a member of the Ig superfamily. In association with integrin α4 or αE chain, β7 forms α4/β7 or αE/β7 heterodimer. α4/β7 (CD49d/β7, LPAM-1) is expressed on the majority of peripheral lymphocytes, on small subsets of thymocytes, and bone marrow progenitors. LPAM-1 binds to several ligands, VCAM-1, MAdCAM-1 and fibronectin, and is involved in lymphocyte adhesion and some hematopoietic progenitor cells migration. αE/β7 (CD103/β7,αIEL/β7) is expressed on intestinal intraepithelial lymphocytes (IEL), dendritic epidermal T cells, T regulatory cells, a subset of CD8+ T cells in lymph nodes and lamina propria. CD103/β7 complex is thought to play a role in lymphocyte retention via interaction with its ligand E-Cadherin.

UniProt: P31809

Pathways: Integrin Complex