alpha Fetoprotein antibody

Catalog No. ABIN7670526

The Mouse Monoclonal anti-alpha Fetoprotein antibody has been validated for ELISA (Capture). It is suitable to detect alpha Fetoprotein in samples from Human.

Quick Overview for alpha Fetoprotein antibody (ABIN7670526)

Target: alpha Fetoprotein (AFP) (alpha-Fetoprotein (AFP))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This alpha Fetoprotein antibody is un-conjugated

Application: ELISA (Capture)

Clone: 6H2

Product Details anti-alpha Fetoprotein Antibody

Purpose: alpha-Fetoprotein/AFP Monoclonal Antibody(Capture)

Purification: Protein A/G Purification

Immunogen: Human AFP Native Protein

Isotype: IgG1

Application Details

Application Notes: ELISA Capture 2-8 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for alpha Fetoprotein

Target: alpha Fetoprotein (AFP) (alpha-Fetoprotein (AFP))

Alternative Name: alpha-Fetoprotein/AFP

Background: ALpha-fetoprotein,ALpha-1-fetoprotein,ALpha-fetogLobuLin,AFP,HPAFP,alpha-Fetoprotein (AFP),is albuminoid superfamily protein that is synthesized in the fetus primarily by the liver,yolk sac,and tissues of gastrointestinal origin. It is one of the earliest markers of the hepatocyte lineage. AFP acts as a carrier protein for steroids,bilirubin,fatty acids,retinoids,and flavonoids. In addition,it can exert immunosuppressive activity,regulate cell proliferation and apoptosis,initiate intracellular signaling,and contribute to cell invasion. Altered levels of both fetal and maternal AFP have been associated with hypothyroidism,autoimmune disorders,and heart defects. low maternal serum AFP levels are associated with a higher incidence of Down syndrome,whereas higher levels are associated with spina bifida and anencephaly. Elevated AFP levels are also coincident with liver,stomach,and germ cell cancers.

UniProt: P02771

Pathways: C21-Steroid Hormone Metabolic Process