ACE2 antibody

Catalog No. ABIN7670534

This Rat Monoclonal antibody specifically detects ACE2 in ELISA (Detection). It exhibits reactivity toward Human.

Quick Overview for ACE2 antibody (ABIN7670534)

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Reactivity: Human

Host: Rat

Clonality: Monoclonal

Conjugate: This ACE2 antibody is un-conjugated

Application: ELISA (Detection)

Clone: 1G5

Product Details anti-ACE2 Antibody

Purpose: ACE2 Monoclonal Antibody(Detector)

Purification: Protein A/G Purification

Immunogen: Recombinant Human ACE2 protein expressed by Mammalian

Isotype: IgG2a

Application Details

Application Notes: ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for ACE2

Target: ACE2 (Angiotensin I Converting Enzyme 2 (ACE2))

Alternative Name: ACE2

Background: ACEH,ACEII,ACE2 (Angiotensin-converting enzyme 2),also named as ACEH,is a zinc metalloprotease of the ACE family and a critical regulator of the reninangiotensin system. ACE2 has a more restricted tissue distribution than ACE,being found predominantly in the heart,kidneys,and testes although low levels have been detected in a variety of tissues. ACE2 has been shown to be a functional receptor of the human coronaviruses SARS-CoV and SARS-CoV-2. The expression level and expression pattern of human ACE2 in different tissues might be critical for the susceptibility,symptoms,and outcome of 2019-nCoV/SARS-CoV-2 infection. It can be used as a potential therapeutic target of SARS-CoV-2. The calculated molecular weight of ACE2 is 92 kDa but it migrates to 120 kDa due to N-glycosylation . Sometimes,several cleaved fragments can also be detected as 75 kDa,50 kDa or 37 kDa. It has 2 isoforms produced by alternative splicing. This antibody is specific to ACE2. The location of ACE2 is membrane and cytoplasm,however it accumulates in the nucleus during the mitosis.

UniProt: Q9BYF1

Pathways: ACE Inhibitor Pathway, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Feeding Behaviour