Cadherin 5 antibody

Catalog No. ABIN7670546

This Rabbit Polyclonal antibody specifically detects Cadherin 5 in ELISA. It exhibits reactivity toward Human.

Quick Overview for Cadherin 5 antibody (ABIN7670546)

Target: Cadherin 5 (CDH5)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cadherin 5 antibody is un-conjugated

Application: ELISA

Product Details anti-Cadherin 5 Antibody

Purpose: VE-Cadherin Polyclonal Antibody(Capture/Detector)

Purification: Antigen Affinity Purification

Immunogen: Recombinant Human VE-Cadherin protein expressed by E.coli

Isotype: IgG

Application Details

Application Notes: ELISA Capture 2-8 μg/mL,ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for Cadherin 5

Target: Cadherin 5 (CDH5)

Alternative Name: VE-Cadherin

Background: CDH5,CD144,Cadherin-5,7B4 antigen,VascuLar endotheLiaL cadherin (VE-cadherin),Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilic manner in connecting cells,cadherins may thus contribute to the sorting of heterogeneous cell types.This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions.It associates with alpha-catenin forming a link to the cytoskeleton.Acts in concert with KRIT1 and PAlS1 to establish and maintain correct endothelial cell polarity and vascular lumen.These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B.Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ,PARD3,TIAM1 and RAP1B to the cell junction.

UniProt: P33151

Pathways: Cell-Cell Junction Organization, Signaling Events mediated by VEGFR1 and VEGFR2