IL-22 antibody

Catalog No. ABIN7670664

The Mouse Monoclonal anti-IL-22 antibody has been validated for ELISA (Capture). It is suitable to detect IL-22 in samples from Human.

Quick Overview for IL-22 antibody (ABIN7670664)

Target: IL-22 (IL22) (Interleukin 22 (IL22))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-22 antibody is un-conjugated

Application: ELISA (Capture)

Clone: 8H8

Product Details anti-IL-22 Antibody

Purpose: IL-22 Monoclonal Antibody(Capture)

Purification: Protein A/G Purification

Immunogen: Recombinant Human IL-22 protein expressed by Mammalian

Isotype: IgG1

Application Details

Application Notes: ELISA Capture 2-8 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for IL-22

Target: IL-22 (IL22) (Interleukin 22 (IL22))

Alternative Name: IL-22

Background: Cytokine Zcyto18,IL-10-reLated T-ceLL-derived inducibLe factor,IL22,IL-22,IL-D110,IL-TIF,ILTIFIL-10-reLated T-ceLL-derived-inducibLe factor,IL-TIFMGC79382,interLeukin 22,interLeukin-22,MGC79384,TIFa,TIFIL-23,zcyto18,Interleukin-22 (Il-22),also known as Il-10-related T cell-derived inducible factor (Il-TIF) was initially identified as a gene induced by Il-9 in mouse T cells and mast cells. Mouse Il-22 cDNA encodes a 179 amino acid (aa) residue protein with a putative 33 aa signal peptide that is cleaved to generate a 147 aa mature protein that shares approximately 79 % and 22 % aa sequence identity with human Il-22 and Il-10,respectively. The mouse Il-22 gene is localized to chromosome 10. Although it exists as a single copy gene in many mouse strains,the Il-22 gene is duplicated in some mouse strains including C57B1/6,FVB and 129. The two mouse genes designated Il-TIF alpha and Il-TIF beta,share greater than 98 % sequence homology in their coding region. Il-22 has been shown to activate STAT1 and STAT3 in several hepatoma cell lines and upregulate the production of acute phase proteins. Il-22 is produced by normal mouse T cells upon Con A activation. Mouse Il-22 expression is also induced in various organs upon lipopolysaccharide injection,suggesting that Il-22 may be involved in inflammatory responses. The functional Il-22 receptor complex consists of two receptor subunits,Il-22 R (previously an orphan receptor named CRF2-9) and Il-10 R beta (previously known as CRF2-4),belonging to the class II cytokine receptor family.

UniProt: Q9GZX6