Osteocalcin antibody

Catalog No. ABIN7670704

This anti-Osteocalcin antibody is a Mouse Monoclonal antibody detecting Osteocalcin in ELISA (Detection). Suitable for Rat.

Quick Overview for Osteocalcin antibody (ABIN7670704)

Target: Osteocalcin (BGLAP)

Reactivity: Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This Osteocalcin antibody is un-conjugated

Application: ELISA (Detection)

Clone: 7G10

Product Details anti-Osteocalcin Antibody

Purpose: Osteocalcin Monoclonal Antibody(Detector)

Purification: Protein A/G Purification

Immunogen: Recombinant Rat Osteocalcin protein expressed by E.coli

Isotype: IgG1

Application Details

Application Notes: ELISA Detector 0.1-0.4 μg/mL

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Sterile PBS , pH 7.4

Preservative: Without preservative

Handling Advice: Avoid freeze / thaw cycles. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C Valid for 1 month or -20°C Valid for 12 months

Expiry Date: 12 months

Target Details for Osteocalcin

Target: Osteocalcin (BGLAP)

Alternative Name: Osteocalcin

Background: OsteocaLcin,Bone GLa protein (BGP),Gamma-carboxygLutamic acid-containing protein,BgLap,BgLap2,The carboxylated form is one of the main organic components of the bone matrix,which constitutes 1-2 % of the total bone protein: it acts as a negative regulator of bone formation and is required to limit bone formation without impairing bone resorption or mineralization. The carboxylated form binds strongly to apatite and calcium. The uncarboxylated form acts as a hormone secreted by osteoblasts,which regulates different cellular processes,such as energy metabolism,male fertility and brain development. Regulates of energy metabolism by acting as a hormone favoring pancreatic beta-cell proliferation,insulin secretion and sensitivity and energy expenditure. Uncarboxylated osteocalcin hormone also promotes testosterone production in the testes: acts as a ligand for G protein-coupled receptor GPRC6A at the surface of leydig cells,initiating a signaling response that promotes the expression of enzymes required for testosterone synthesis in a CREB-dependent manner. Also acts as a regulator of brain development: osteocalcin hormone crosses the blood-brain barrier and acts as a ligand for GPR158 on neurons,initiating a signaling response that prevents neuronal apoptosis in the hippocampus,favors the synthesis of all monoamine neurotransmitters and inhibits that of gamma-aminobutyric acid (GABA). Osteocalcin also crosses the placenta during pregnancy and maternal osteocalcin is required for fetal brain development.

UniProt: P04640