8-OHDG antibody

Catalog No. ABIN7672607

This Rabbit Polyclonal antibody specifically detects 8-OHDG in IHC and IF. It exhibits reactivity toward .

Quick Overview for 8-OHDG antibody (ABIN7672607)

Target: 8-OHDG (8-Hydroxyguanosine (8-OHDG))

Host: Rabbit

Clonality: Polyclonal

Conjugate: This 8-OHDG antibody is un-conjugated

Application: Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-8-OHDG Antibody

Purpose: 8-OHDG antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: KLH conjugated 8-OHdG

Isotype: IgG

Application Details

Application Notes: IHC: 1:50 - 1:500, IF: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.06 % PC300 and 50 % glycerol pH 7.3,

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for 8-OHDG

Target: 8-OHDG (8-Hydroxyguanosine (8-OHDG))

Alternative Name: 8-OHDG

Target Type: Chemical

Background:

Synonyms: 8-hydroxy-2'-deoxyguanosine|2'-Deoxy-8-oxoguanosine|7,8-Dihydro-8-oxo-2'-deoxyguanosine|8-Oxo-7,8-dihydro-2'-deoxyguanosine|8-Oxo-7,8-dihydrodeoxyguanosine|2'-Deoxy-8-oxo-D-guanosine|8-Oxo-7,8-dihydro-2μ-deoxyguanosine,8-Oxo-dG|2'-Deoxy-8-hydroxyguanosine

Background: 8-Hydroxydeoxyguanosine (8OHdG) is a modified base that occurs in DNA due to attack by hydroxyl radicals that are formed as byproducts and intermediates of aerobic metabolism and during oxidative stress. There is increasing evidence to support the involvement of free radical reactions in the damage of biomolecules that eventually lead to several diseases in humans, such as atherosclerosis, cerebral and heart ischemia-reperfusion injury, cancer, rheumatoid arthritis, inflammation, diabetes, aging, and neurodegenerative conditions, such as Alzheimer's disease.