Acetyl-CoA Carboxylase alpha antibody (AA 2223-2346)

Catalog No. ABIN7672612

This anti-Acetyl-CoA Carboxylase alpha antibody is a Mouse Monoclonal antibody detecting Acetyl-CoA Carboxylase alpha in WB, IHC and ELISA. Suitable for Human and Mouse.

Quick Overview for Acetyl-CoA Carboxylase alpha antibody (AA 2223-2346) (ABIN7672612)

Target: Acetyl-CoA Carboxylase alpha (ACACA)

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Acetyl-CoA Carboxylase alpha antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Clone: 9D2

Product Details anti-Acetyl-CoA Carboxylase alpha Antibody

Binding Specificity: AA 2223-2346

Purpose: ACC1 antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 2223-2346aa

Immunogen: acetyl-Coenzyme A carboxylase alpha

Isotype: IgG2a

Application Details

Application Notes: WB: 1:2000-1:10000, IHC: 1:100-1:500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for Acetyl-CoA Carboxylase alpha

Target: Acetyl-CoA Carboxylase alpha (ACACA)

Alternative Name: ACC1

Background:

Synonyms: Acetyl-CoA carboxylase 1 (ACC1)|Acetyl-Coenzyme A carboxylase alpha (ACC-alpha)|ACACA|ACAC|ACC1|ACCA

Background: ACACA(Acetyl-CoA carboxylase 1, ACC), also named as ACAC, ACC1 and ACCA, belongs to the biotin containing enzyme family. It catalyzes the synthesis of malonyl-CoA, which is an intermediate substrate playing a pivotal role in the regulation of fatty acid metabolism and energy production. ACACA is involved in the biosynthesis of fatty acids, and malonyl-CoA produced is used as a building block to extend the chain length of fatty acids by fatty acid synthase(FAS)(PMID:19900410). It has 4 isoforms produced by alternative promoter usage with the molecular weight between 260 kDa and 270 kDa.

Molecular Weight: 270 kDa

Gene ID: 31

UniProt: Q13085

Pathways: AMPK Signaling, Ribonucleoside Biosynthetic Process, Warburg Effect