ST5 antibody

Catalog No. ABIN7673013

The Rabbit Polyclonal anti-ST5 antibody is suitable to detect ST5 in samples from Human and Rat. It has been validated for WB, ELISA and IHC.

Quick Overview for ST5 antibody (ABIN7673013)

Target: ST5 (Suppression of Tumorigenicity 5 (ST5))

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ST5 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-ST5 Antibody

Purpose: DENND2B antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen: suppression of tumorigenicity 5

Isotype: IgG

Application Details

Application Notes: WB: 1:500 - 1:2000, IHC: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for ST5

Target: ST5 (Suppression of Tumorigenicity 5 (ST5))

Alternative Name: DENND2B

Background:

Synonyms: DENN domain-containing protein 2B|HeLa tumor suppression 1|Suppression of tumorigenicity 5 protein|DENND2B|HTS1|ST5

Background: Guanine nucleotide exchange factor(GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth.

Molecular Weight: 150 kDa

Gene ID: 6764

UniProt: P78524