GNA13 antibody (AA 1-200)

Catalog No. ABIN7673325

The Rabbit Polyclonal anti-GNA13 antibody is suitable to detect GNA13 in samples from Human, Mouse and Rat. It has been validated for WB, IHC and IF.

Quick Overview for GNA13 antibody (AA 1-200) (ABIN7673325)

Target: GNA13 (Guanine Nucleotide Binding Protein (G Protein), alpha 13 (GNA13))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GNA13 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-GNA13 Antibody

Binding Specificity: AA 1-200

Purpose: GNA13 antibody

Purification: Immunogen affinity purified

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-200aa

Immunogen: guanine nucleotide binding protein (G protein), alpha 13

Isotype: IgG

Application Details

Application Notes: WB: 1:500-1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for GNA13

Target: GNA13 (Guanine Nucleotide Binding Protein (G Protein), alpha 13 (GNA13))

Alternative Name: GNA13

Background:

Synonyms: Guanine nucleotide-binding protein subunit alpha-13 (G alpha-13, G-protein subunit alpha-13)|GNA13

Background: Guanine nucleotide-binding proteins (G proteins are involved as modulators or transducers in various transmembrane signaling systems. Activates effector molecule RhoA by binding and activating RhoGEFs (ARHGEF1/p115RhoGEF, ARHGEF11/PDZ-RhoGEF and ARHGEF12/LARG. GNA13-dependent Rho signaling subsequently regulates transcription factor AP-1 (activating protein-1 (By similarity. Promotes tumor cell invasion and metastasis by activating RhoA/ROCK signaling pathway. Inhibits CDH1-mediated cell adhesion in process independent from Rho activation.

Molecular Weight: 44 kDa

UniProt: Q14344

Pathways: CXCR4-mediated Signaling Events