Haptoglobin antibody (AA 180-406)

Catalog No. ABIN7673380

This anti-Haptoglobin antibody is a Mouse Monoclonal antibody detecting Haptoglobin in WB and ELISA. Suitable for Human and Pig.

Quick Overview for Haptoglobin antibody (AA 180-406) (ABIN7673380)

Target: Haptoglobin (HP)

Reactivity: Human, Pig

Host: Mouse

Clonality: Monoclonal

Conjugate: This Haptoglobin antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 7C8

Product Details anti-Haptoglobin Antibody

Binding Specificity: AA 180-406

Purpose: HP antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 180-406aa

Immunogen: haptoglobin

Isotype: IgG2a

Application Details

Application Notes: WB: 1:2000 - 1:20000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for Haptoglobin

Target: Haptoglobin (HP)

Alternative Name: HP

Background:

Synonyms: Haptoglobin|Zonulin|Haptoglobin alpha chain|Haptoglobin beta chain|HP

Background: As a result of hemolysis, hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures, and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial, Antioxidant, has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin, also known as zonulin, plays a role in intestinal permeability, allowing intercellular tight junction disassembly, and controlling the equilibrium between tolerance and immunity to non-self antigens.

Molecular Weight: 42 kDa

Gene ID: 3240

UniProt: P00738

Pathways: Transition Metal Ion Homeostasis