ITGA2 antibody (PE-Cy5.5)

Catalog No. ABIN7673977

This anti-ITGA2 antibody is a Rat Monoclonal antibody detecting ITGA2 in FACS. Suitable for Mouse.

Quick Overview for ITGA2 antibody (PE-Cy5.5) (ABIN7673977)

Target: ITGA2 (Integrin alpha 2 (ITGA2))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This ITGA2 antibody is conjugated to PE-Cy5.5

Application: Flow Cytometry (FACS)

Clone: DX5

Product Details anti-ITGA2 Antibody (PE-Cy5.5)

Purpose: PE-Cy5.5 Anti-Mouse CD49b/pan-NK cells Antibody

Purification: 0

Purity: 0

Isotype: IgM, kappa

Application Details

Application Notes: Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0. 1 % sodium azide, 1 % BSA, pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: 4 °C

Storage Comment: 2-8°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for ITGA2

Target: ITGA2 (Integrin alpha 2 (ITGA2))

Alternative Name: CD49b

Background:

Synonyms: CD49 antigen-like family member B|CD49b|Collagen receptor|GPIa|Integrin alpha-2|Platelet membrane glycoprotein Ia|VLA-2 subunit alpha|pan-NK cells

Background: DX5 antigen has been recently characterized as CD49b. It is a 150 kD integrin α chain also known as α2 integrin, VLA-2 α chain, and integrin α2 chain. CD49b non-covalently associates with CD29 (β1 integrin) to form the CD49b/CD29 complex known as VLA-2, a receptor for collagen and laminin. CD49b is expressed on platelets, the majority of NK cells, NKT cells, and a small subset of CD8+ T cells (this population can be significantly increased following viral infection). DX5 is used for the identification and isolation of NK cells, and is especially useful for identifying NK cells in mice lacking the NK1.1 antigen.

Molecular Weight: 0

Gene ID: 16398

UniProt: Q62469

Pathways: CXCR4-mediated Signaling Events, Smooth Muscle Cell Migration, Integrin Complex