EIF2S1 antibody (pSer51)

Catalog No. ABIN7674371

This Mouse Monoclonal antibody specifically detects EIF2S1 in WB and ELISA. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for EIF2S1 antibody (pSer51) (ABIN7674371)

Target: EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1))

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This EIF2S1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: 9I7

Product Details anti-EIF2S1 Antibody

Binding Specificity: pSer51

Purpose: Phospho-EIF2S1 antibody antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: Peptide

Immunogen: eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa

Isotype: IgG1

Application Details

Application Notes: WB: 1:1000-1:10000

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for EIF2S1

Target: EIF2S1 (Eukaryotic Translation Initiation Factor 2 Subunit 1 (EIF2S1))

Alternative Name: EIF2S1

Background:

Synonyms: Eukaryotic translation initiation factor 2 subunit 1|Eukaryotic translation initiation factor 2 subunit alpha (eIF-2-alpha, eIF-2A, eIF-2alpha, eIF2-alpha)|EIF2S1|EIF2A

Background: Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Molecular Weight: 36 kDa

Gene ID: 1965

UniProt: P05198

Pathways: Ribonucleoprotein Complex Subunit Organization, ER-Nucleus Signaling, Hepatitis C