14-3-3 theta antibody (AA 1-245)

Catalog No. ABIN7674607

This anti-14-3-3 theta antibody is a Mouse Monoclonal antibody detecting 14-3-3 theta in WB, ELISA, IHC and IF. Suitable for Human, Mouse and Rat.

Quick Overview for 14-3-3 theta antibody (AA 1-245) (ABIN7674607)

Target: 14-3-3 theta (YWHAQ)

Reactivity: Human, Mouse, Rat

Host: Mouse

Clonality: Monoclonal

Conjugate: This 14-3-3 theta antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Clone: 8D2

Product Details anti-14-3-3 theta Antibody

Binding Specificity: AA 1-245

Purpose: YWHAQ antibody

Purification: Protein A+G purification

Purity: ≥95 % as determined by SDS-PAGE

Immunogen:

Immunogen sequence: 1-245aa

Immunogen: tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

Isotype: IgG1

Application Details

Application Notes: WB: 1:1000-1:10000, IHC: 1:20-1:200, IF: 1:20-1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide and 50 % glycerol pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: -20 °C

Storage Comment: -20°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for 14-3-3 theta

Target: 14-3-3 theta (YWHAQ)

Alternative Name: YWHAQ

Background:

Synonyms: 14-3-3 protein theta|14-3-3 protein T-cell|14-3-3 protein tau|Protein HS1|YWHAQ

Background: 14-3-3 theta(also known as YWHAQ, or 14-3-3 tau) is a member of 14-3-3 proteins which were the first phosphoserine/phosphothreonine-binding proteins to be discovered. 14-3-3 family members interact with a wide spectrum of proteins and possess diverse functions. Mammals express seven distinct 14-3-3 isoforms(gamma, epsilon, beta, zeta, sigma, theta, tau) that form multiple homo-and hetero-dimmers. 14-3-3 proteins display the highest expression levels in the brain, and have been implicated in several neurodegenerative diseases, including Alzheimer's disease and amyotrophic lateral sclerosis. This antibody was raised against full-length 14-3-3 theta.

Molecular Weight: 28 kDa

Gene ID: 10971

UniProt: P27348

Pathways: Apoptosis, Myometrial Relaxation and Contraction