CD72 antibody (FineTest®700)

Catalog No. ABIN7675253

This anti-CD72 antibody is a Mouse Monoclonal antibody detecting CD72 in FACS. Suitable for Human.

Quick Overview for CD72 antibody (FineTest®700) (ABIN7675253)

Target: CD72 (CD72 Molecule (CD72))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD72 antibody is conjugated to FineTest®700

Application: Flow Cytometry (FACS)

Clone: 3F3

Product Details anti-CD72 Antibody (FineTest®700)

Purpose: FineTest®700 Anti-Human CD72 Antibody

Isotype: IgG2b, kappa

Application Details

Application Notes: Volume per test: 5μL. Each lot of this antibody is quality control tested by flow cytometric analysis. The amount of the reagent is suggested to be used 5 μL of antibody per test (million cells in 100 μL staining volume or per 100 μL of whole blood). Please check your vial before the experiment. Since applications vary, the appropriate dilutions must be determined for individual use.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0. 1 % sodium azide, 1 %BSA, pH 7.3,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freeze / thaw cycles.

Storage: 4 °C

Storage Comment: 2-8°C for 12 months (Avoid repeated freeze / thaw cycles.)

Expiry Date: 12 months

Target Details for CD72

Target: CD72 (CD72 Molecule (CD72))

Alternative Name: CD72

Background:

Synonyms: Lyb-2|Ly-19.2|Ly-32.2

Background: CD72 is a 39-43 kD type II membrane glycoprotein. It is a disulfide-linked homodimer belonging to C-type lectin family. CD72 is a pan-B cell marker expressed on pre-pre-B cells throughout B cell differentiation with the exception of plasma cells. It is also expressed on follicular dendritic cells, splenic red pulp macrophages (but not on peripheral blood monocytes), and liver Kupffer cells. CD72, a negative coreceptor of B cells, contains immunoreceptor tyrosine-based inhibitory motifs in the cytoplasmic domain which has been shown to recruit the tyrosine phosphatase SHP-1. Ligation of CD72 with its ligand regulates CD72 tyrosine dephosphorylation and SHP-1 dissociation to promote B cell activation and proliferation. CD100 and CD5 have been shown to be CD72 ligands. The CD100-CD72 interaction plays a role in maintenance of B cell homeostasis.

Molecular Weight: 0

Gene ID: 971

UniProt: P21854

Pathways: BCR Signaling