Transferrin Receptor antibody (AA 21-120)

Catalog No. ABIN734378

Product Details anti-Transferrin Receptor Antibody

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Binding Specificity: AA 21-120

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Transferrin Receptor antibody is un-conjugated

Application: Flow Cytometry (FACS), ELISA

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Pig,Horse,Chicken

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Transferrin receptor

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
FCM 1:20-100

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Transferrin Receptor antibody (ABIN734378)

Gao, Bai, Wang, Sun, Guan, Zheng: "All-trans retinoic acid promotes nerve cell differentiation of yolk sac-derived mesenchymal stem cells." in: Applied biochemistry and biotechnology, Vol. 174, Issue 2, pp. 682-92, (2014) (PubMed).

Gao, Bai, Xiong, Li, Shan, Huang, Ma, Guan: "Isolation and characterization of chicken dermis-derived mesenchymal stem/progenitor cells." in: BioMed research international, Vol. 2013, pp. 626258, (2013) (PubMed).

Target Details for Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Alternative Name: Transferrin receptor (TFRC Products)

Background:

Synonyms: Transferrin receptor protein 1, TR, TfR, TfR1, Trfr, T9, p90, TFRC

Background: Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

Molecular Weight: 95kDa

Gene ID: 7037

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis