Prostaglandin E Synthase antibody (PE-Cy7)

Catalog No. ABIN735801

This anti-Prostaglandin E Synthase antibody is a Rabbit Polyclonal antibody detecting Prostaglandin E Synthase in WB. Suitable for Human, Rat, Mouse and Guinea Pig.

Quick Overview for Prostaglandin E Synthase antibody (PE-Cy7) (ABIN735801)

Target: Prostaglandin E Synthase (PTGES)

Reactivity: Human, Rat, Mouse, Guinea Pig

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Prostaglandin E Synthase antibody is conjugated to PE-Cy7

Application: Western Blotting (WB)

Product Details anti-Prostaglandin E Synthase Antibody (PE-Cy7)

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Pig,Guinea Pig

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PTGEs

Isotype: IgG

Application Details

Application Notes: FCM(1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for Prostaglandin E Synthase

Target: Prostaglandin E Synthase (PTGES)

Alternative Name: PTGEs

Background:

Synonyms: PGES, MPGES, PIG12, PP102, PP1294, MGST-IV, MGST1L1, TP53I12, mPGES-1, MGST1-L1, Prostaglandin E synthase, Microsomal glutathione S-transferase 1-like 1, Microsomal prostaglandin E synthase 1, p53-induced gene 12 protein, PTGES, MPGES1

Background: Prostaglandin E synthase catalyses conversion of COX derived PGH2 to PGE2. It is a member of the MAPEG family. It may contribute to the pathogenesis of collagen induced arthritis and mediate acute pain during inflammatory responses.The protein encoded by this gene is a glutathione-dependent prostaglandin E synthase. The expression of this gene has been shown to be induced by proinflammatory cytokine interleukin 1 beta (IL1B). Its expression can also be induced by tumor suppressor protein TP53, and may be involved in TP53 induced apoptosis. Knockout studies in mice suggest that this gene may contribute to the pathogenesis of collagen-induced arthritis and mediate acute pain during inflammatory responses.

Molecular Weight: 17kDa

Gene ID: 9536

UniProt: O14684