TGM3 antibody (AA 601-693)

Catalog No. ABIN736253

There is 1 publication for this product available. The Rabbit Polyclonal anti-TGM3 antibody is suitable to detect TGM3 in samples from Mouse and Rat. It has been validated for ELISA, IF (cc), IF (p), IHC (fro) and IHC (p).

Quick Overview for TGM3 antibody (AA 601-693) (ABIN736253)

Target: TGM3 (Transglutaminase 3 (E Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM3))

Reactivity: Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TGM3 antibody is un-conjugated

Application: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-TGM3 Antibody

Binding Specificity: AA 601-693

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human,Dog,Cow,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human TGM3

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-TGM3 antibody (ABIN736253)

Kawabe, Takano, Moriyama, Nakamura: "Transglutaminases Derived from Astrocytes Accelerate Amyloid β Aggregation." in: Neurochemical research, Vol. 42, Issue 8, pp. 2384-2391, (2017) (PubMed).

Target Details for TGM3

Target: TGM3 (Transglutaminase 3 (E Polypeptide, Protein-Glutamine-gamma-Glutamyltransferase) (TGM3))

Alternative Name: TGM3

Background:

Synonyms: TGE, Protein-glutamine gamma-glutamyltransferase E, Transglutaminase E, TG(E), TGase E, Transglutaminase-3, TGase-3, TGM3

Background: Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath.

Gene ID: 7053

UniProt: Q08188