Marburg Virus GP1 antibody

Catalog No. ABIN7794770

This Mouse Monoclonal antibody specifically detects Marburg Virus GP1 in ELISA, IEM and Neut. It exhibits reactivity toward Marburg Virus.

Quick Overview for Marburg Virus GP1 antibody (ABIN7794770)

Target: Marburg Virus GP1

Reactivity: Marburg Virus

Host: Mouse

Clonality: Monoclonal

Application: ELISA, Immunoelectron Microscopy (IEM), Neutralization (Neut)

Clone: MARV-72

Product Details

Purpose: Anti-Marburg Virus, Glycoprotein (GP1) (Clone MARV-72)-Purified No Carrier Protein

Specificity: Clone MARV-72 is a human IgG monoclonal antibody that specifically targets the top portion from the head domain of glycoprotein 1 (GP1) of the Marburg Virus (MARV). Antigen Distribution MARV initially infects monocytes, macrophages, and dendritic cells, which serve as the initial targets of infection and contribute to the spread of the virus throughout the body. Background MARV is a highly pathogenic virus that belongs to the Filoviridae family, along with Ebola virus1. It can cause severe hemorrhagic fever in humans, with mortality rates as high as 90 % 2. MARV is transmitted to humans through contact with infected animals, such as fruit bats or monkeys, or direct contact with the bodily fluids of infected individuals3. There are currently no approved vaccines or specific treatments for MARV infection. Research has focused on understanding the virus's replication, immune evasion mechanisms, and developing potential vaccines and therapeutics. Animal models, such as nonhuman primates and guinea pigs, have been used to study the virus and evaluate potential interventions.? Studies on MARV's envelope GP have shown that the virus can evade antibody-mediated immune pressure through mutations in the furin-cleavage site and deletion of the mucin-like region, demonstrating the GP's structural flexibility and variability4. These findings contribute to our understanding of MARV's life cycle, immune evasion mechanisms, and potential therapeutic approaches. Clone MARV-72 (also known as MR72) is recognized for its wide-ranging reactivity against filoviruses, such as Ebola and Marburg viruses. It is noteworthy for being one of the rare antibodies capable of attaching to GPs of both types of viruses, making it highly sought after for therapeutic applications. MARV-72 has demonstrated its efficacy in neutralizing these viruses and offering protection in non-human primate models5.

Purification: Recombinant antibodies are manufactured in an animal free facility using only in vitro protein free cell culture techniques and are purified by a multi-step process including the use of protein A or G to assure extremely low levels of endotoxins, leachable protein A or aggregates.

Purity: >=90 % monomer by analytical SEC and SDS-Page

Isotype: IgG1

Application Details

Restrictions: For Research Use only

Handling

Concentration: 1 μg/mL

Buffer: This recombinant monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.

Preservative: Without preservative

Storage: 4 °C,-80 °C

Storage Comment: This antibody may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at <= -70°C.Avoid Repeated Freeze Thaw Cycles.

Target Details

Target: Marburg Virus GP1

Target Type: Viral Protein