Anti-West Nile virus (Clone WNV-3562) is specific for WNV non-structural protein 1 (NS1). There is no cross-reactivity with other Flavivirus. Background West Nile Virus (WNV) is a mosquito-borne, enveloped, positive-stranded RNA flavivirus1. Flavivirus nonstructural protein NS1 has been proposed as an antibody target to avoid antibody-dependent enhancement2. NS1 is a 46-55 kDa glycoprotein that is expressed as a dimer on the cell surface and as a soluble hexamer in the extracellular space and in circulation during infection. WNV NS1 dimer consists of a AY-roll, wing, and AY-ladder.
Purification
This monoclonal antibody is purified by ion exchange chromatography.
Formulated in 0.015 M phosphate buffered saline (0.85 % NaCl), pH 7.2 and contains 0.05 % sodium azide. Due to inherent biochemical properties of antibodies, certain products may be prone to precipitation over time. Precipitation may be removed by aseptic centrifugation and/or filtration.
Preservative
Sodium azide
Precaution of Use
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage
4 °C
Storage Comment
This purified antibody is stable when stored at 2-8°C. Do not freeze.