Recombinant Trop2 (Sacituzumab Biosimilar) antibody

Catalog No. ABIN7795132

This anti-Trop2 (Sacituzumab Biosimilar) antibody is a Humanized Monoclonal antibody detecting Trop2 (Sacituzumab Biosimilar) in FACS and in vivo. Suitable for Human.

Quick Overview for Recombinant Trop2 (Sacituzumab Biosimilar) antibody (ABIN7795132)

Target: Trop2 (Sacituzumab Biosimilar)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Humanized

Clonality: Monoclonal

Conjugate: This Trop2 (Sacituzumab Biosimilar) antibody is un-conjugated

Application: Flow Cytometry (FACS), In vivo Studies (in vivo)

Grade: Research Grade

Product Details anti-Trop2 (Sacituzumab Biosimilar) Antibody

Expression System: Mammalian cells

Purpose: Sacituzumab Biosimilar, Trop-2 Monoclonal Antibody

Characteristics: What is sacituzumab biosimilar research grade? Sacituzumab Biosimilar uses the same protein sequences as the therapeutic antibody sacituzumab. Sacituzumab govitecan is a Trop-2-directed antibody and topoisomerase inhibitor drug conjugate used for the treatment of metastatic triple-negative breast cancer and metastatic urothelial cancer. Triple-negative breast cancer is a type of breast cancer that tests negative for estrogen receptors, progesterone receptors and human epidermal growth factor receptor 2 (HER2) protein. Therefore, triple-negative breast cancer does not respond to hormonal therapy medicines or medicines that target HER2. Sacituzumab govitecan is a conjugate of the humanized anti-Trop-2 monoclonal antibody linked with SN-38, the active metabolite of irinotecan. Each antibody having on average 7.6 Molecules of SN-38 attached. SN-38 is too toxic to administer directly to patients, but linkage to an antibody allows the drug to specifically target cells containing Trop-2.

Purification: Protein A or G affinity column

Purity: >95 % by reducing SDS-PAGE

Endotoxin Level: < 1 EU per 1 mg of the protein by the LAL method

Immunogen: Human Trop-2

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: > 3 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.

Target Details for Trop2 (Sacituzumab Biosimilar)

Target: Trop2 (Sacituzumab Biosimilar)

Alternative Name: Sacituzumab Biosimilar

Target Type: Biosimilar