Recombinant PD-1 & VEGF-A antibody

Catalog No. ABIN7795547

This Mouse Bispecific antibody specifically detects PD-1 & VEGF-A in ELISA, FACS, ICC, IHC, in vivo and WB. It exhibits reactivity toward Mouse.

Quick Overview for Recombinant PD-1 & VEGF-A antibody (ABIN7795547)

Target: PD-1 & VEGF-A

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Mouse

Clonality: Bispecific

Conjugate: Un-conjugated

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (IHC), In vivo Studies (in vivo), Western Blotting (WB)

Grade: In vivo Grade

Clone: RMP1-14-1-G6-23

Product Details

Expression System: Mammalian cells

Purpose: In Vivo Grade Recombinant Anti-mouse PD-1 / VEGF-A Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone RMP1-14.1 / G6-23)

Characteristics: The rat anti-mouse PD-1 monoclonal antibody (clone No. RMP1-14, rat IgG2a kappa) reacts with the mouse PD-1 protein (CD279 or programmed death-1) encoded by the mouse pdcd1 gene, a member of the CD28 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2, both of which belong to the B7 family. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD 1 antibody and the anti-mouse PD L1 antibody which block the interaction between the PD-L1 protein and its receptor PD-1 protein. The RMP1-14 antibody blocks the binding of both the mouse PD-L1 protein and the mouse PD-L2 protein to the mouse PD-1 protein. It is under investigation how the recombinant anti-mouse PD-1 / VEGF-A bispecific antibodies (RMP1-14.1 / G6-23) behave different from the individual monoclonal antibodies and their combination. Our recombinant anti-mouse PD-1 / VEGF-A bispecific antibodies have a part (variable regions) or complete amino acid sequences of the rat anti-mouse PD-1 antibody (hybridoma clone name or number: RMP1-14) and the mouse anti-mouse VEGF-A antibody (hybridoma clone name or number: G6-23).

Purification: Protein A or G affinity column

Purity: >95 % by reducing SDS-PAGE

Endotoxin Level: < 1 EU per 1 mg of the protein by the LAL method

Isotype: IgG2c, L234A, L235A, P329G, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: > 3 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.

Target Details

Target: PD-1 & VEGF-A

Sub Type: Bispecific