Recombinant PD-L1 & VEGFR-2 antibody

Catalog No. ABIN7795555

The Mouse Bispecific anti-PD-L1 & VEGFR-2 antibody (Clone 10F-9G2-1-DC101) (ABIN7795555) specifically detects PD-L1 & VEGFR-2 in ELISA, FACS, ICC, IHC, in vivo and WB. The antibody is reactive with Mouse samples.

Quick Overview for Recombinant PD-L1 & VEGFR-2 antibody (ABIN7795555)

Target: PD-L1 & VEGFR-2

Antibody Type: Recombinant Antibody

Reactivity: Mouse

Host: Mouse

Clonality: Bispecific

Application: ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC), Immunohistochemistry (IHC), In vivo Studies (in vivo), Western Blotting (WB)

Grade: In vivo Grade

Clone: 10F-9G2-1-DC101

Product Details

Expression System: Mammalian cells

Purpose: In Vivo Grade Recombinant Anti-mouse PD-L1 / VEGFR-2 Bispecific Antibody, Mouse IgG2c LALAPG Kappa (Clone 10F.9G2.1 / DC101)

Characteristics: The rat anti-mouse PD-L1 monoclonal antibody 10F.9G2 (rat IgG2b kappa) reacts with the mouse PD-L1 protein (programmed death ligand-1, B7-H1 or CD274), a member of the B7 family of the Ig superfamily. PD-1 has two ligands, PD-L1 and PD-L2. It has been shown that in mouse models of melanoma, tumor growth can be transiently arrested via treatment with the anti-mouse PD-1 and anti-mouse PD-L1 antibodies which block the interaction between the PD-L1 protein and its receptor PD-1 protein. The 10F.9G2 monoclonal antibody blocks the binding of the mouse PD-L1 protein to the mouse PD-1 protein. It is under investigation how the recombinant anti-mouse PD-L1 / VEGFR-2 bispecific antibodies (10F.9G2.1 / DC101) behave different from the individual monoclonal antibodies and their combination. Our recombinant anti-mouse PD-L1 / VEGFR-2 bispecific antibodies have a part (variable regions) or complete amino acid sequences of the rat anti-mouse PD-L1 antibody (hybridoma clone name or number: 10F.9G2) and the rat anti-mouse VEGFR-2 antibody (hybridoma clone name or number: DC101).

Purification: Protein A or G affinity column

Purity: >95 % by reducing SDS-PAGE

Endotoxin Level: < 1 EU per 1 mg of the protein by the LAL method

Isotype: IgG2c, L234A, L235A, P329G, kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: > 3 mg/mL

Storage: 4 °C,-20 °C

Storage Comment: Short time 2 to 8°C as supplied. Long time -20°C to -70°C as supplied.

Target Details

Target: PD-L1 & VEGFR-2

Sub Type: Bispecific