TS (C-Term) antibody

Catalog No. ABIN7795593

The Rabbit Polyclonal anti-TS antibody is suitable to detect TS in samples from Human and Mouse. It has been validated for WB, IHC and IP.

Quick Overview for TS (C-Term) antibody (ABIN7795593)

Target: TS

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details

Binding Specificity: C-Term

Purpose: Rabbit anti-TS Antibody Affinity Purified

Predicted Reactivity: Bovine,Dog,Monkey,Pig,Rabbit,Rat

Purification: Antigen Affinity Purified

Immunogen: Between 263 and C-terminus

Isotype: IgG

Application Details

Application Notes: IHC,1500 - 12000. Epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.,IP,6 μg/mg lysate,WB,12000 - 110,000

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1000 μg/mL

Buffer: Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09 % Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: 2 - 8 °C

Expiry Date: 12 months

Target Details

Target: TS

Background: Thymidylate synthetase (TS) catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. TS is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs [taken from NCBI Entrez Gene (Gene ID: 7298)].

Gene ID: 7298

UniProt: P04818