Serotonin Receptor 1A antibody (AA 301-400)

Catalog No. ABIN738006

Cited in 3+ publications. The Rabbit Polyclonal anti-Serotonin Receptor 1A antibody (ABIN738006) specifically detects Serotonin Receptor 1A in WB, ELISA, IF (cc), IF (p) and IHC (fro). The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for Serotonin Receptor 1A antibody (AA 301-400) (ABIN738006)

Target: Serotonin Receptor 1A (HTR1A)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Serotonin Receptor 1A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Serotonin Receptor 1A Antibody

Binding Specificity: AA 301-400

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from rat 5-HTR1A

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Serotonin Receptor 1A antibody (ABIN738006)

García-Pedraza, Fernández-González, López, Martín, Alarcón-Torrecillas, Rodríguez-Barbero, Morán, García-Domingo: "Oral fluoxetine treatment changes serotonergic sympatho-regulation in experimental type 1 diabetes." in: Life sciences, Vol. 293, pp. 120335, (2022) (PubMed).

Yeh, Weng, Chang, Chan, Huang, Chu, Wei, Ma, Cheng, Ma, Chen, Shyu: "Calcitonin alleviates hyperalgesia in osteoporotic rats by modulating serotonin transporter activity." in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, Vol. 27, Issue 11, pp. 3355-3364, (2016) (PubMed).

Zhou, Wu, Zhou, Liu, Lee, Liu, Devkota, Ro, Zhu, Suh: "Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert(-/-) mice." in: Translational psychiatry, Vol. 6, Issue 6, pp. e836, (2016) (PubMed).

Target Details for Serotonin Receptor 1A

Target: Serotonin Receptor 1A (HTR1A)

Alternative Name: 5-HTR1A

Background:

Synonyms: 5HT1A, RAT5HT1A, 5-hydroxytryptamine receptor 1A, 5-HT-1A, 5-HT1A, Serotonin receptor 1A, Htr1a

Background: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.

Gene ID: 24473

UniProt: P19327

Pathways: JAK-STAT Signaling, Synaptic Membrane, Feeding Behaviour