Serotonin Receptor 1A antibody (AA 301-400)

Catalog No. ABIN738006

This anti-Serotonin Receptor 1A antibody is a Rabbit Polyclonal antibody detecting Serotonin Receptor 1A in WB, ELISA, IF (cc), IF (p) and IHC (fro). Suitable for Human, Rat and Mouse. This Primary Antibody has been cited in 3+ publications.

Quick Overview for Serotonin Receptor 1A antibody (AA 301-400) (ABIN738006)

Target: Serotonin Receptor 1A (HTR1A)

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Serotonin Receptor 1A antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-Serotonin Receptor 1A Antibody

Binding Specificity: AA 301-400

Cross-Reactivity: Human, Mouse, Rat

Predicted Reactivity: Dog,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from rat 5-HTR1A

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-Serotonin Receptor 1A antibody (ABIN738006)

García-Pedraza, Fernández-González, López, Martín, Alarcón-Torrecillas, Rodríguez-Barbero, Morán, García-Domingo: "Oral fluoxetine treatment changes serotonergic sympatho-regulation in experimental type 1 diabetes." in: Life sciences, Vol. 293, pp. 120335, (2022) (PubMed).

Yeh, Weng, Chang, Chan, Huang, Chu, Wei, Ma, Cheng, Ma, Chen, Shyu: "Calcitonin alleviates hyperalgesia in osteoporotic rats by modulating serotonin transporter activity." in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, Vol. 27, Issue 11, pp. 3355-3364, (2016) (PubMed).

Zhou, Wu, Zhou, Liu, Lee, Liu, Devkota, Ro, Zhu, Suh: "Reactivation of Tert in the medial prefrontal cortex and hippocampus rescues aggression and depression of Tert(-/-) mice." in: Translational psychiatry, Vol. 6, Issue 6, pp. e836, (2016) (PubMed).

Target Details for Serotonin Receptor 1A

Target: Serotonin Receptor 1A (HTR1A)

Alternative Name: 5-HTR1A

Background:

Synonyms: 5HT1A, RAT5HT1A, 5-hydroxytryptamine receptor 1A, 5-HT-1A, 5-HT1A, Serotonin receptor 1A, Htr1a

Background: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.

Gene ID: 24473

UniProt: P19327

Pathways: JAK-STAT Signaling, Synaptic Membrane, Feeding Behaviour