Influenza A Matrix Protein 2 antibody (Influenza A Virus) (AA 2-60) (Biotin)

Catalog No. ABIN739061

The Rabbit Polyclonal anti- antibody has been validated for ELISA, IHC (fro) and IHC (p). It is suitable to detect in samples from Influenza A Virus and Virus.

Quick Overview for Influenza A Matrix Protein 2 antibody (Influenza A Virus) (AA 2-60) (Biotin) (ABIN739061)

Target: Influenza A Matrix Protein 2 (M2)

Reactivity: Influenza A Virus, Virus

Host: Rabbit

Clonality: Polyclonal

Conjugate: Biotin

Application: ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details

Binding Specificity: AA 2-60

Specificity: This antibody will recognize many Influenza A virus strains

Cross-Reactivity: Virus

Cross-Reactivity (Details): Influenza A virus

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from Influenza A virus H5N1 Matrix Protein-2

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details

Target: Influenza A Matrix Protein 2 (M2)

Alternative Name: Influenza A virus Matrix Protein 2

Target Type: Influenza Protein

Background:

Synonyms: Avian influenza Matrix Protein-2, Influenza A virus H7N7 H9N2 H13N6 H16N3 H1N1 N2N1 H3N2 H2N2

Background: Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry. After attaching to the cell surface, the virion enters the cell by endocytosis. Acidification of the endosome triggers M2 ion channel activity. The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein (RNP), matrix protein 1 (M1), and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur. Also plays a role in viral proteins secretory pathway. Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation