SPTAN1 antibody (AA 30-110)

Catalog No. ABIN739415

The Rabbit Polyclonal anti-SPTAN1 antibody has been validated for ICC, ELISA, IHC (p), IF (cc), IF (p) and IHC (fro). It is suitable to detect SPTAN1 in samples from Rat.

Quick Overview for SPTAN1 antibody (AA 30-110) (ABIN739415)

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Reactivity: Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SPTAN1 antibody is un-conjugated

Application: Immunocytochemistry (ICC), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-SPTAN1 Antibody

Binding Specificity: AA 30-110

Cross-Reactivity: Rat

Predicted Reactivity: Human,Mouse,Dog,Cow

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Spectrin alpha chain, non-erythrocytic 1

Isotype: IgG

Application Details

Application Notes: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
other()
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for SPTAN1

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Alternative Name: Spectrin alpha Chain, Non-Erythrocytic 1

Background:

Synonyms: SPTN1_HUMAN, Alpha Fodrin, Spectrin-Alpha, SPEC, Spectrin, alpha, non-erythrocy tic 1 variant, Spectrin alpha chain, non-erythrocytic 1, Alpha-II spectrin, Fodrin alpha chain, Spectrin, non-erythroid alpha subunit, SPTAN1, SPTA2, alpha-II spectrin, spectrin, non-erythroid alpha chain, alpha-fodrin, spectrin, non-erythroid alpha subunit, spectrin alpha chain, non-erythrocytic 1, EIEE5, NEAS.

Background: Spectrins are a family of filamentous cytoskeletal proteins that function as essential scaffold proteins that stabilize the plasma membrane and organize intracellular organelles. Spectrins are composed of alpha and beta dimers that associate to form tetramers linked in a head-to-head arrangement. This gene encodes an alpha spectrin that is specifically expressed in nonerythrocytic cells. The encoded protein has been implicated in other cellular functions including DNA repair and cell cycle regulation. Mutations in this gene are the cause of early infantile epileptic encephalopathy-5. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Sep 2010].

Gene ID: 6709

Pathways: Caspase Cascade in Apoptosis, Regulation of Actin Filament Polymerization