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MDC1 antibody (AA 31-130) (Biotin)

MDC1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IHC (fro) Host: Rabbit Polyclonal Biotin

Catalog No. ABIN739742

Datasheet as PDF

Target See all MDC1 Antibodies

MDC1 (Mdc1 (MDC1))
Binding Specificity
22

17

14

10

5

3

2

2

2

1

1

1

1

1

1

1

1

1
AA 31-130
Reactivity
59

53

15

12

11

2

1

1
Human, Mouse, Rat
Host
49

37
Rabbit
Compatible Secondaries
Clonality
49

37
Polyclonal
Conjugate
30

6

5

4

3

3

3

3

3

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
This MDC1 antibody is conjugated to Biotin
Application
67

31

13

13

13

13

12

10

8

6

2

2

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity

Human, Mouse, Rat

Predicted Reactivity

Dog,Cow,Pig,Horse

Purification

Purified by Protein A.

Immunogen

KLH conjugated synthetic peptide derived from human MDC1

Isotype

IgG

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MDC1 Reactivity: Human WB, IF, IHC (p), ICC Host: Rabbit Polyclonal unconjugated

anti-Mdc1 (MDC1) (AA 1-100) antibody
MDC1 Reactivity: Human WB, IHC, IF Host: Rabbit Polyclonal unconjugated

anti-Mdc1 (MDC1) (AA 31-130) antibody
MDC1 Reactivity: Human, Mouse, Rat WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Host: Rabbit Polyclonal unconjugated

anti-Mdc1 (MDC1) (N-Term) antibody
MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 unconjugated

anti-Mdc1 (MDC1) (N-Term) antibody (Alkaline Phosphatase (AP))
MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 Alkaline Phosphatase (AP)

anti-Mdc1 (MDC1) (N-Term) antibody (HRP)
MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 HRP

anti-Mdc1 (MDC1) (N-Term) antibody (FITC)
MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 FITC

anti-Mdc1 (MDC1) (N-Term) antibody (Atto 488)
MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 Atto 488

anti-Mdc1 (MDC1) (N-Term) antibody (Biotin)
MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 Biotin

anti-Mdc1 (MDC1) (N-Term) antibody (PE)
MDC1 Reactivity: Mouse WB, IF, ICC Host: Mouse Monoclonal P2B11 PE

Application Notes

WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions

For Research Use only
Format

Liquid

Concentration

1 μg/μL

Buffer

Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative

ProClin

Precaution of Use

This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage

-20 °C

Storage Comment

Store at -20°C for 12 months.

Expiry Date

12 months
Target

MDC1 (Mdc1 (MDC1))

Alternative Name

MDC1 (MDC1 Products)

Background

Synonyms: NFBD1, Mediator of DNA damage checkpoint protein 1, Nuclear factor with BRCT domains 1, MDC1, KIAA0170
Background: Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.

Gene ID

9656

UniProt

Q14676