FOXM1 antibody (AA 457-760)

Catalog No. ABIN7825381

The Rabbit Polyclonal anti-FOXM1 antibody is suitable to detect FOXM1 in samples from Human, Rat and Mouse. It has been validated for WB, ELISA, IHC and IP.

Quick Overview for FOXM1 antibody (AA 457-760) (ABIN7825381)

Target: FOXM1 (Forkhead Box M1 (FOXM1))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FOXM1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP)

Product Details anti-FOXM1 Antibody

Binding Specificity: AA 457-760

Purpose: Anti-FOXM1 Antibody

Cross-Reactivity (Details): No cross-reactivity with other proteins

Characteristics: Anti-FOXM1 Antibody catalog # A00659-2. Tested in WB, IHC, ELISA, IP applications. This antibody reacts with Human, Mouse, Rat. This is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications.

Purification: Immunogen affinity purified.

Immunogen: E.coli-derived human FOXM1 recombinant protein (Position: Q457-P760).

Isotype: IgG

Application Details

Application Notes: Western blot, 0.25-0.5 μg/mL, Human, Mouse, Rat
Immunohistochemistry, 2-5 μg/mL, Human
Immunoprecipitation, 0.5-2 μg/mL, Human
ELISA, 0.1-0.5 μg/m, -l

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL.

Concentration: 500 μg/mL

Buffer: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Storage: 4 °C,-20 °C

Storage Comment: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month.
It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Target Details for FOXM1

Target: FOXM1 (Forkhead Box M1 (FOXM1))

Alternative Name: FOXM1

Background: Forkhead box protein M1, also called FOXM1, is a protein that in humans is encoded by the FOXM1 gene. It is mapped to 12p13.33. The protein encoded by this gene is a member of the FOX family of transcription factors. FOXM1 is known to play a key role in cell cycle progression where endogenous FOXM1 expression peaks at S and G2/M phases and also in the control of cell proliferation. FOXM1 gene is now known as a human proto-oncogene. Abnormal upregulation of FOXM1 is involved in the oncogenesis of basal cell carcinoma, the most common human cancer worldwide. It was hypothesized that FOXM1 induces cancer initiation through stem/progenitor cell expansion. What's more, FOXM1 has been shown to modulate the epigenome. It was found that overexpression of FOXM1 brain washes normal cells to adopt cancer-like epigenome.

Molecular Weight: 100-110 kDa

UniProt: Q08050

Pathways: Positive Regulation of Response to DNA Damage Stimulus