Recombinant Aconitase 1 antibody

Catalog No. ABIN7827991

This Rabbit Monoclonal antibody specifically detects Aconitase 1 in WB. It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for Recombinant Aconitase 1 antibody (ABIN7827991)

Target: Aconitase 1 (ACO1)

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Aconitase 1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: A583

Product Details anti-Aconitase 1 Antibody

Purpose: Recombinant Aconitase 1/ACO1 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human Aconitase 1/ACO1 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:2000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for Aconitase 1

Target: Aconitase 1 (ACO1)

Alternative Name: Aconitase 1/ACO1

Background: HEL,IRP,ACO,IREB,ACO1,ACONS,HEL60,IREB1,IREBP,IREBP1,IRP1,ACO 1,ACOC,Aconitase,Aconitase 1 soluble,Aconitase1,Aconitate hydratase,Citrate hydro lyase,Citrate hydro-lyase,Cytoplasmic aconitate hydratase,Ferritin repressor protein,IRE BP 1,IREB 1,IRE-BP 1,Iron regulatory protein 1,Iron responsive element binding protein 1,Iron-responsive element-binding protein 1,IRP 1,OTTHUMP00000045233,Aconitase 1 is a bifunctional, cytosolic protein that functions as an essential enzyme in the TCA cycle and interacts with mRNA to control the levels of iron inside cells. When cellular iron levels are high, this protein binds to a 4Fe-4S cluster and functions as an aconitase. Aconitases are iron-sulfur proteins that function to catalyze the conversion of citrate to isocitrate. When cellular iron levels are low, the protein binds to iron-responsive elements (IREs), which are stem-loop structures found in the 5' UTR of ferritin mRNA, and in the 3' UTR of transferrin receptor mRNA. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 98 kDa

Observed MW: 105 kDa The actual band is not consistent with the expectation.

UniProt: P21399

Pathways: Transition Metal Ion Homeostasis