Recombinant ABCB11 antibody

Catalog No. ABIN7828030

This Rabbit Monoclonal antibody specifically detects ABCB11 in IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant ABCB11 antibody (ABIN7828030)

Target: ABCB11 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ABCB11 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: A145

Product Details anti-ABCB11 Antibody

Purpose: Recombinant ABCB11/BSEP Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human ABCB11/BSEP fragment

Isotype: IgG, kappa

Application Details

Application Notes: IHC 1:200-1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for ABCB11

Target: ABCB11 (ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 11 (ABCB11))

Alternative Name: ABCB11/BSEP

Background: PGY,ABC,ABCB,BRIC,ABCB11,ABC16,BRIC2,BSEP,PFIC-2,PFIC2,PGY4,SPGP,Catalyzes the transport of the major hydrophobic bile salts, such as taurine and glycine-conjugated cholic acid across the canalicular membrane of hepatocytes in an ATP-dependent manner, therefore participates to hepatic bile acids homeostasis and consequently to lipid homeostasis through regulation of biliary lipid secretion in a bile salts dependent manner. Transports taurine-conjugated bile salts more rapidly than glycine-conjugated bile salts. Also transports non-bile acid compounds, such as pravastatin and fexofenadine in an ATP-dependent manner and may be involved in their biliary excretion. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

UniProt: O95342