Recombinant ABCE1 antibody

Catalog No. ABIN7828031

The Rabbit Monoclonal anti-ABCE1 antibody is suitable to detect ABCE1 in samples from Human and Mouse. It has been validated for WB and IF.

Quick Overview for Recombinant ABCE1 antibody (ABIN7828031)

Target: ABCE1 (ATP-Binding Cassette, Sub-Family E (OABP), Member 1 (ABCE1))

Antibody Type: Recombinant Antibody

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This ABCE1 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF)

Clone: A119

Product Details anti-ABCE1 Antibody

Purpose: Recombinant ABCE1 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human ABCE1 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:1000,IF 1:50

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for ABCE1

Target: ABCE1 (ATP-Binding Cassette, Sub-Family E (OABP), Member 1 (ABCE1))

Alternative Name: ABCE1

Background: ABC,ABCE,RNASEL,OK/SW-cl,ABCE1,ABC38,OABP,RLI,RLI1,RNASEL1,RNASELI,RNS4I,OK/SW-cl.40,2' 5' oligoadenylate binding protein,2'5' oligoadenylate binding protein,2''-5''-oligoadenylate-binding protein,ABC 38,ABCE 1,ATP binding cassette sub family E (OABP) member 1,ATP binding cassette sub family E member 1,ATP-binding cassette sub-family E member 1,HuHP 68,HuHP68,Ribonuclease 4 inhibitor,Ribonuclease L (2' 5' oligoisoadenylate synthetase dependent) inhibitor,Ribonuclease L (2'5' oligoisoadenylate synthetase dependent) inhibitor,Ribonuclease L inhibitor,RNase L inhibitor,RNS 4I,Cotranslational quality control factor involved in the No-Go Decay (NGD) pathway. Together with PELO and HBS1L, is required for 48S complex formation from 80S ribosomes and dissociation of vacant 80S ribosomes. Together with PELO and HBS1L, recognizes stalled ribosomes and promotes dissociation of elongation complexes assembled on non-stop mRNAs, this triggers endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and to degrade damaged mRNAs as part of the No-Go Decay (NGD) pathway. Plays a role in the regulation of mRNA turnover. Plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage, this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy. RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL. Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 34 kDa

Observed MW: 45 kDa The actual band is not consistent with the expectation.

UniProt: P61221