Recombinant Caveolin-1 antibody (pTyr14)

Catalog No. ABIN7828072

This Rabbit Monoclonal antibody specifically detects Caveolin-1 in WB. It exhibits reactivity toward Human.

Quick Overview for Recombinant Caveolin-1 antibody (pTyr14) (ABIN7828072)

Target: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Caveolin-1 antibody is un-conjugated

Application: Western Blotting (WB)

Clone: A813

Product Details anti-Caveolin-1 Antibody

Binding Specificity: pTyr14

Purpose: Recombinant Phospho-Caveolin-1 (Tyr14) Monoclonal Antibody

Purification: Protein A purified

Immunogen: phosphorylated human Caveolin-1 (Tyr14) peptide

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for Caveolin-1

Target: Caveolin-1 (CAV1) (Caveolin 1, Caveolae Protein, 22kDa (CAV1))

Alternative Name: Caveolin-1

Background: PPH,CGL,BSCL,MSTP,cell growth-inhibiting protein,OTTHUMP,VIP,BSCL3,CGL3,LCCNS,MSTP085,PPH3,VIP21,CAV1,22 kD,caveolae protein,caveolin 1 alpha isoform,caveolin 1 beta isoform,Caveolin 1 caveolae protein 22 kDa,Caveolin1,Caveolin-1,cell growth-inhibiting protein 32,OTTHUMP00000025031,VIP 21,CAV,Caveolins are the principal structural components of the cholesterol/sphingolipid-enriched plasma membrane microdomain caveolae. Three members of the caveolin family (caveolin-1, -2, and -3) have been identified with different tissue distributions. Caveolins form hetero- and homo-oligomers that interact with cholesterol and other lipids. Caveolins are involved in diverse biological functions, including vesicular trafficking, cholesterol homeostasis, cell adhesion, and apoptosis, and are also implicated in neurodegenerative disease. Caveolins interact with multiple signaling molecules, such as Gα subunit, tyrosine kinase receptors, PKCs, Src family tyrosine kinases, and eNOS. It is believed that caveolins serve as scaffolding proteins for the integration of signal transduction. Phosphorylation at Tyr14 is essential for caveolin association with SH2 or PTB domain-containing adaptor proteins, such as GRB7. Phosphorylation at Ser80 regulates caveolin binding to the ER membrane and entry into the secretory pathway. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 20 kDa

Observed MW: 22 kDa The actual band is not consistent with the expectation.

UniProt: Q03135

Pathways: Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2, Negative Regulation of Transporter Activity, VEGFR1 Specific Signals