Recombinant CD33 antibody

Catalog No. ABIN7828081

This Rabbit Monoclonal antibody specifically detects CD33 in IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant CD33 antibody (ABIN7828081)

Target: CD33

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD33 antibody is un-conjugated

Application: Immunohistochemistry (IHC)

Clone: A170

Product Details anti-CD33 Antibody

Purpose: Recombinant CD33 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human CD33 fragment

Isotype: IgG, kappa

Application Details

Application Notes: IHC 1:200-1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for CD33

Target: CD33

Alternative Name: CD33

Background: CD33,SIGLEC-3,SIGLEC3,p67,CD33 Molecule,gp67,Myeloid cell surface antigen CD33,Sialic acid-binding Ig-like lectin 3,Siglec-3,CD33 Molecule,p67,SIGLEC3,Sialic-acid-binding immunoglobulin-like lectin (Siglec) that plays a role in mediating cell-cell interactions and in maintaining immune cells in a resting state. Upon engagement of ligands such as C1q or syalylated glycoproteins, two immunoreceptor tyrosine-based inhibitory motifs (ITIMs) located in CD33 cytoplasmic tail are phosphorylated by Src-like kinases such as LCK. These phosphorylations provide docking sites for the recruitment and activation of protein-tyrosine phosphatases PTPN6/SHP-1 and PTPN11/SHP-2. In turn, these phosphatases regulate downstream pathways through dephosphorylation of signaling molecules. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

UniProt: P20138