Recombinant CD3G antibody

Catalog No. ABIN7828083

The Rabbit Monoclonal anti-CD3G antibody (Clone A172) (ABIN7828083) specifically detects CD3G in WB, IHC, IP and IF. The antibody is reactive with Human samples.

Quick Overview for Recombinant CD3G antibody (ABIN7828083)

Target: CD3G (CD3g Molecule, gamma (CD3-TCR Complex) (CD3G))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CD3G antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP), Immunofluorescence (IF)

Clone: A172

Product Details anti-CD3G Antibody

Purpose: Recombinant CD3G Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human CD3G fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:1000,IHC 1:500-1:2000,IF 1:50,IP 1:50

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for CD3G

Target: CD3G (CD3g Molecule, gamma (CD3-TCR Complex) (CD3G))

Alternative Name: CD3G

Background: T3G,CD3G,T3,CD_antigen: CD3g,CD3g molecule,CD3-GAMMA,IMD17,T-cell receptor T3 gamma chain,T-cell surface glycoprotein CD3 gamma chain,Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition to this role of signal transduction in T-cell activation, CD3G plays an essential role in the dynamic regulation of TCR expression at the cell surface. Indeed, constitutive TCR cycling is dependent on the di-leucine-based (diL) receptor-sorting motif present in CD3G. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 20 kDa

Observed MW: 18-28 kDa The actual band is not consistent with the expectation.

UniProt: P09693

Pathways: TCR Signaling, CXCR4-mediated Signaling Events