Recombinant CCR6 antibody

Catalog No. ABIN7828105

This Rabbit Monoclonal antibody specifically detects CCR6 in WB and IHC. It exhibits reactivity toward Human.

Quick Overview for Recombinant CCR6 antibody (ABIN7828105)

Target: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This CCR6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A154

Product Details anti-CCR6 Antibody

Purpose: Recombinant CCR6 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human CCR6 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:25000-1:50000,IHC 1:500-1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for CCR6

Target: CCR6 (Chemokine (C-C Motif) Receptor 6 (CCR6))

Alternative Name: CCR6

Background: DCR,DRY,GPR,CKRL,STRL,CKR-L,CMKBR,GPRCY,CC-CKR,C-C CKR,CCR,CCR6,BN-1,C-C CKR-6,CC-CKR-6,CCR-6,CD196,CKR-L3,CKRL3,CMKBR6,DCR2,DRY6,GPR29,GPRCY4,STRL22,BN 1,BN1,C C chemokine receptor type 6,C C CKR 6,CC chemokine receptor type 6,C-C chemokine receptor type 6,CC CKR 6,CC R6,CCCKR6,CCR 6,CD 196,CD196 antigen,Chemokine (C C motif) receptor 6,Chemokine (C C) receptor 6,Chemokine (CC motif) receptor 6,Chemokine (CC) receptor 6,Chemokine receptor 6,Chemokine receptor like 3,Chemokine receptor-like 3,CKR 6,CKR L3,CKR6,CMKBR 6,DCR 2,DRY 6,G protein coupled receptor 29,GPR 29,GPR CY4,GPRCY 4,GPR-CY4,G-protein coupled receptor 29,LARC receptor,Seven transmembrane receptor lymphocyte 22,STRL 22,Receptor for the C-C type chemokine CCL20. Binds to CCL20 and subsequently transduces a signal by increasing the intracellular calcium ion levels. Although CCL20 is its major ligand it can also act as a receptor for non-chemokine ligands such as beta-defensins. Binds to defensin DEFB1 leading to increase in intracellular calcium ions and cAMP levels. Its binding to DEFB1 is essential for the function of DEFB1 in regulating sperm motility and bactericidal activity. Binds to defensins DEFB4 and DEFB4A/B and mediates their chemotactic effects. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/ memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and various autoimmune diseases. CCR6-mediated signals are essential for immune responses to microbes in the intestinal mucosa and in the modulation of inflammatory responses initiated by tissue insult and trauma. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 42 kDa

Observed MW: 42 kDa

UniProt: P51684

Pathways: cAMP Metabolic Process