Recombinant Claudin 1 antibody

Catalog No. ABIN7828115

The Rabbit Monoclonal anti-Claudin 1 antibody is suitable to detect Claudin 1 in samples from Human. It has been validated for WB, IHC and IP.

Quick Overview for Recombinant Claudin 1 antibody (ABIN7828115)

Target: Claudin 1 (CLDN1)

Antibody Type: Recombinant Antibody

Reactivity: Human

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Claudin 1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Clone: A187

Product Details anti-Claudin 1 Antibody

Purpose: Recombinant Claudin-1 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human Claudin-1 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:2000,IHC 1:200-1:1000,IP 1:50-1:100

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for Claudin 1

Target: Claudin 1 (CLDN1)

Alternative Name: Claudin-1

Background: UNQ,PRO,CLD,CLDN1,CLD1,ILVASC,SEMP1,claudin-1,Claudin1,CLD 1,CLDN 1,SEMP 1,Senescence associated epithelial membrane protein,Senescence associated epithelial membrane protein 1,Senescence-associated epithelial membrane protein,UNQ481,PRO944,claudin-1,CLD1,ILVASC,SEMP1,Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 22 kDa

Observed MW: 18 kDa The actual band is not consistent with the expectation.

UniProt: O95832

Pathways: Cell-Cell Junction Organization, Hepatitis C