Recombinant Clusterin antibody

Catalog No. ABIN7828120

This Rabbit Monoclonal antibody specifically detects Clusterin in WB. It exhibits reactivity toward Rat and Mouse.

Quick Overview for Recombinant Clusterin antibody (ABIN7828120)

Target: Clusterin (CLU)

Antibody Type: Recombinant Antibody

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This Clusterin antibody is un-conjugated

Application: Western Blotting (WB)

Clone: A616

Product Details anti-Clusterin Antibody

Purpose: Recombinant Clusterin beta Chain Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human Clusterin beta Chain fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:1000

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for Clusterin

Target: Clusterin (CLU)

Alternative Name: Clusterin beta Chain

Background: KUB,AAG,Ku70-binding protein,Sulfated glycoprotein,Complement-associated protein SP,Testosterone-repressed prostate message,NA1/NA,SGP,CLU,AAG4,APO-J,APOJ,CLI,CLU1,CLU2,KUB1,NA1/NA2,SGP-2,SGP2,SP-40,TRPM-2,TRPM2,clusterin,CLUS,Aging-associated gene 4 protein,Apolipoprotein J,Complement cytolysis inhibitor,Complement-associated protein SP-40,Ku70-binding protein 1,Sulfated glycoprotein2,Testosterone-repressed prostate message 2,Complement cytolysis inhibitor a chain,Clusterin alpha chain,Complement cytolysis inhibitor b chain,APOJ CLI,Sulfated glycoprotein 2,Clusterin (CLU) also named as apolipoprotein J, is a multifunctional glycoprotein that is expressed ubiquitously in most tissues. Clusterin functions as a secreted chaperone protein that interacts with and stabilizes stress-induced proteins to prevent their precipitation. Research studies show that clusterin plays a protective role in Alzheimer's disease by sequestering amyloid β (1-40) peptides to form long-lived, stable complexes, which prevents amyloid fibril formation.In addition to the secreted protein, several intracellular isoforms are localized to the nucleus, mitochondria, cytoplasm and ER. The subcellular distribution of these multiple isoforms leads to the diversity of clusterin functions. Additional studies report that clusterin is involved in membrane recycling, cell adhesion, cell proliferation, apoptosis, and tumor survival. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 52 kDa

Observed MW: 35 kDa The actual band is not consistent with the expectation.

UniProt: P10909

Pathways: Apoptosis, Negative Regulation of intrinsic apoptotic Signaling