Recombinant GABRA1 antibody

Catalog No. ABIN7828217

The Rabbit Monoclonal anti-GABRA1 antibody is suitable to detect GABRA1 in samples from Rat, Human and Mouse. It has been validated for WB and IHC.

Quick Overview for Recombinant GABRA1 antibody (ABIN7828217)

Target: GABRA1 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))

Antibody Type: Recombinant Antibody

Reactivity: Rat, Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: This GABRA1 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Clone: A523

Product Details anti-GABRA1 Antibody

Purpose: Recombinant GABA A Receptor alpha 1 Monoclonal Antibody

Purification: Protein A purified

Immunogen: Recombinant human GABA A Receptor alpha 1 fragment

Isotype: IgG, kappa

Application Details

Application Notes: WB 1:500-1:2000,IHC 1:50-1:100

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: PBS, 50 % glycerol, 0.05 % Proclin 300, 0.05 % protein protectant.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C Valid for 12 months. Avoid freeze / thaw cycles.

Expiry Date: 12 months

Target Details for GABRA1

Target: GABRA1 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 1 (GABRA1))

Alternative Name: GABA A Receptor alpha 1

Background: Gabra-1,Gabra1,GABA A Receptor alpha 1 is a subunit of the GABA A receptor protein. GABA A receptor consists of different combinations of five protein subunits, each produced from a different gene. These subunits form a hole (pore) in the cell membrane through which negatively charged chlorine atoms (chloride ions) can flow. A chemical that transmits signals in the brain (a neurotransmitter) called gamma-amino butyric acid (GABA) attaches to GABA A receptors. Once GABA attaches, the pore formed by the subunits opens, and chloride ions flow across the cell membrane. After infancy, chloride ions flow into the cell through the open pore, which creates an environment in the cell that blocks (inhibits) signaling between neurons. The primary role of GABA in children and adults is to prevent the brain from being overloaded with too many signals. In contrast, in newborns and infants, chloride ions flow out of the cell when the pore is opened, creating an environment that allows signaling between neurons. Cat.No. Product Name Clone No. IF:{{item.impact}} Journal:{{item.journal}} ({{item.year}}) DOI:{{item.doi}} Reactivity:{{item.species}} Sample Type:{{item.sample_type}} Previous {{ page }} Next Q{{(FAQpage.currentPage - 1)*pageSize+index+1}}:{{item.name}} Previous {{ page }} Next [

Molecular Weight:

Calculated MW: 52 kDa

Observed MW: 52 kDa

UniProt: P62812